Lose, and Arsenal will take a giant step towards becoming league champions for the first time in 20 years.

Draw, and the big winner this weekend could be Liverpool.

With 10 rounds to go, the clash at Etihad Stadium is the last time any of the three title rivals will go head to head.

Arsenal lead the league. Liverpool are second on goal difference. City are a point behind both of them.

An element of risk and reward hangs over City and Arsenal.

History is clearly on City's side, having won their last eight home games against the Gunners. City's last home loss in this fixture was in 2015.

But Arsenal have been better this season after beating City in a penalty shootout to win the Community Shield in August, followed by a 1-0 victory at Emirates Stadium in October.

City manager Pep Guardiola's preparations haven't been helped by injuries to key defenders Kyle Walker and John Stones during the international break.

Mikel Arteta was once Guardiola's trusted lieutenant at City. Arteta was spoken of as a future City manager but is working on creating his own legacy at Arsenal after transforming the club's fortunes since taking charge in 2019.

He has been backed with money and time, and that faith has paid off with Arsenal leading the league and advancing to the Champions League quarter-finals. After falling away badly at the end of last season to allow City to take the English title, it remains to be seen if Arteta and his players have learned from that experience.

Those two wins against City this season suggest Arsenal are more prepared to go head to head against the champions.

Arsenal stand as the last major test for City, who have arguably the smoothest run of games to the end of the league. Arsenal and Liverpool both have to travel to Manchester United and face respective derbies against Tottenham and Everton.

All three teams still have to face Aston Villa and Spurs, who are competing for fourth spot and Champions League qualification.

Liverpool play Brighton on Sunday with the chance to go top of the standings before City and Arsenal kick off.

There is little to choose between the challengers.

City are on an ominous 22-game unbeaten run in all competitions, dating to the start of December.

Liverpool have lost two of their last 23 games and already have their first trophy of the season after winning the English League Cup in February.

One of those defeats was Manchester United's extra-time winner in the FA Cup quarter-finals this month. The other was 3-1 to Arsenal in the league in February.

Arsenal, meanwhile, have risen to the top of the league on the back of an eight-game winning streak.

All three teams are battling on multiple fronts.

City are defending their Premier League, Champions League and FA Cup treble of last season.

Liverpool are no longer competing for a quadruple, but after winning the League Cup are also still in contention for the Europa League.

Arsenal are in the Champions League quarters, where they next face Bayern Munich.

City were given the toughest draw of all against Real Madrid.

Guardiola could make history by winning back-to-back trebles including an unprecedented fourth Premier League in a row. Not even Alex Ferguson managed that at Man United.

Arsenal will be driven to make amends for last season's title collapse after leading the table for 248 days, the longest of any team that hasn't gone on to be crowned champions.

Liverpool manager Juergen Klopp is on his farewell tour. He's stepping down at the end of the season and the best send off would be a second league title.

Australian Associated Press